New insight into how HIV destroys the immune system leads to drug that partially blocks the process: more clinical studies required

Madely Health Headlines Commentary for December 23, 2013

Source:

New AIDS treatment? Experimental drug blocks HIV from killing immune system cells in lab test

Reference:

  1. Gilad Doitsh, Nicole L. K. Galloway, Xin Geng, Zhiyuan Yang, Kathryn M. Monroe, Orlando Zepeda, Peter W. Hunt, Hiroyu Hatano, Stefanie Sowinski, Isa Muñoz-Arias, Warner C. Greene. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infectionNature, 2013; DOI:10.1038/nature12940
  2. K. M. Monroe, Z. Yang, J. R. Johnson, X. Geng, G. Doitsh, N. J. Krogan, W. C. Greene. IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIVScience, 2013; DOI: 10.1126/science.1243640
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