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Category: Genomics

Sunday House Call, #424, December  16, 2012

Special edition on atrial fibrillation and sudden cardiac death in athletes

Dr. Michael Gollob is a native of Toronto,Ontario, and obtained an undergraduate degree in molecular genetics at the University of Toronto, graduating as a Gold Medalist.  He then entered the field of medicine and is now a Clinical Electrophysiologist at The University of Ottawa Heart Institute.  His clinical and research interests combine his expertise in both genetics and arrhythmia disorders. He is the Director of The Inherited Arrhythmia Clinic and Arrhythmia Research Laboratory at the Ottawa Heart Institute.

Dr. Gollob’s research focuses on the genetic and physiological basis of cardiac arrhythmia syndromes, including sudden death syndromes and the common arrhythmia of atrial fibrillation. He has Chaired on behalf of the CCS the first document outlining the appropriate use of genetic testing for cardiac diseases associated with a risk of sudden death.

 

 

Here in Ottawa, research continues to follow exciting avenues towards the goal of treating cancer. Innovative and elegant solutions are being applied in clinical trials. One such approach is the use of oncoviruses, viruses that target and destroy cancer cells leaving normal cells in peace. At the Ottawa Health Research Institute and the Ottawa Hospital [...]

Multiple Sclerosis (MS) was first identified and described by a French neurologist, Dr. Jean-Martin Charcot, in 1868. It is the most common neurological disease affecting young adults in Canada. Women are twice as likely to develop MS as men. Every day, three more people in Canada are diagnosed with it. It can cause loss of [...]

As cancer research continues apace, there is a growing understanding of the genetic abnormalities that are intimately involved in the pathophysiology of the disease process. Understanding the mechanism of the disease allows clinical research to develop targeted treatments to better control or eradicate the tumours. A new diagnostic test created at the University of Alberta [...]

A consortium of Canadian and American researchers led by Dr. John D. Rioux, PhD, Associate Professor of Medicine at the Montreal Heart Institute and the Université de Montréal, report in the April 15, 2007 online edition of Nature Genetics the results from a search of the entire human genome for genetic risk factors leading to [...]

What is pharmacogenomics? What research is taking place in pharmacogenomics right now? What role will it play in patient care as we try to live longer, even following cancer, diabetes, heart & stroke? Pharmacogenomics is an emerging science that integrates the patient’s genomic data so as to personalize treatment and thereby improve the effectiveness and [...]

Last week I talked about how researchers had uncovered a new genetic mechanism that could explain why some people develop inflammatory bowel diseases like Ulcerative colitis and Crohn’s. The discovery by a six-member Inflammatory Bowel Disease (IBD) Genetics Consortium of a genetic risk factor for IBD was reported in Science Express, the online publication of [...]

We have seen numerous studies in basic science research produce results that surprise the investigator and open up new insights into the pathophysiology or mechanism of disease. A study published in the July 13, 2006 online issue of the Journal of Clinical Investigation found that a protein previously linked to the development of type 2 [...]

Genetic research continues to broaden our understanding of the mechanism or pathophysiology of diseases. Reports seem to present themselves daily about new avenues for treatments of once incurable or uncontrollable illnesses. A team from the Scripps Research Institute and the University of California School of Medicine has developed compounds that reactivate the gene responsible for [...]