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Category: Pathophysiology

There are many branches of stroke research from prevention, emergency treatment, to rehabilitation technologies and therapies. When a person suffers a stroke, it is a race to try to minimize the death of brain cells that follow the initial damage and oxygen deprivation.

Original broadcast date: April 26, 2009 Several shows back on Sunday House Call we talked about biofilms with Darla Geores, Research engineer with the Center for Biofilm Engineering and Assistant Research Professor, Chemical & Biological Engineering at Montana State University, who is conducting research sponsored by the EPA to develop a protocol to assess the [...]

Original broadcast date: March 8, 2009 Through much of medical history, the approach to treating disease has been akin to using a blunt instrument to carpet bomb an area. The side effects that many treatments create is testament to the fact more than the region of the body we wish to target is being affected. [...]

Original broadcast date: March 9, 2008 With a greater understanding behind the mechanism or pathophysiology of disease, the ability to provide effective treatments can follow. An international consortium of scientists led by Oklahoma Medical Research Foundation investigator John B. Harley, M.D., Ph.D., has identified multiple genes linked to lupus, a devastating autoimmune disease that affects [...]

Original broadcast date: February 24, 2008 Ulcerative Colitis is one of several inflammatory bowel diseases that damages the large intestine. It is a chronic autoimmune disease affecting about 65,000 Canadians with 4,000 new cases reported annually. Treatments are varied and each confronts various aspects of the pathophysiology of the disease. Dr. Hillary Steinhart, MD MSc [...]

Original broadcast date: February 17, 2008 How long are survival rates after a diagnosis of heart failure? A study published in the February issue of American Heart Journal sought to answer this question and answer it it did. Dr. Dennis Ko, lead author and ICES scientist, Interventional cardiologist at Schulich Heart Centre, Sunnybrook Health Sciences [...]

Original broadcast date: January 13, 2008 Why do some people suffer a severe allergic reaction or anaphylaxis while others do not when both are exposed to the same allergen? From a clinical standpoint, anaphylaxis can be difficult to diagnose because it is highly variable in its presentation and its signs and symptoms overlap with life-threatening [...]

Bipolar disorder is an inheritable illness that leads to extreme mood swings. About one in 100 Canadians suffer from this condition over their lifetime. Efforts are being made to understand the pathophysiology or mechanism of the disease process. Researchers at UCLA are contributing to this understanding. In the July issue of the journal Biological Psychiatry, [...]

A new study released this week by the Canadian Heart and Stroke Foundation outlines some new information regarding stroke risk factors especially among women. What are these risk factors and how can they be incorporated into preventive measures against the development of stroke? Dr. Michael Hill, neurologist, Director of the Stroke Unit at Foothills Medical [...]

Researchers at The Hospital for Sick Children (SickKids), the University of Calgary and The Jackson Laboratory, Bar Harbor, Maine have found a new mechanism that is directly involved in the pathophysiology of diabetes. This new insight into the mechanism of diabetes has advanced possible new treatment strategies, with the potential as seen in animal trials [...]

What makes a particular strain of the flu more aggressive than others? Is there a disease model that can explain why the severity of flu seasons can vary? A study published in October 2006 in the online journal Biology Direct, researchers suggest that one possible avenue to explain these variations is an ongoing competition between [...]