Here in Ottawa, research continues to follow exciting avenues towards the goal of treating cancer. Innovative and elegant solutions are being applied in clinical trials. One such approach is the use of oncoviruses, viruses that target and destroy cancer cells leaving normal cells in peace. At the Ottawa Health Research Institute and the Ottawa Hospital [...]
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Archive
Category: Genetics
Original broadcast date: September 13, 2009 There are instances in clinical research when the clinical outcome goals of the study are superseded by an unexpected discovery. Researchers from the University of Florida reported in the August 13, 2009 edition of the New England Journal of Medicine that the retinas of adults treated with a gene [...]
Original broadcast date: June 28, 2009 What do cancer cells need to survive? We know that gene mutations contribute to the development of cancer and research continues to identify the aberrant genetic sequences as cataloged in the Cancer Genome Atlas. However, are mutations and the proteins that they code for the principle components that ensure [...]
Original broadcast date: May 31, 2009 How well can cancer specialists, oncologists, assess how well a particular treatment is destroying a tumour? It is true that there are methods to make this determination but it could take weeks of observation before knowing whether the tumour has shrunk. Is it possible to develop a means of [...]
Original broadcast date: March 22, 2009 Are you getting what you ordered when dining in a restaurant that serves seafood? This is important on many levels, from honest business practices to endangered or protected species preservation to managing allergy risks. How can inspectors, and by extension the public, learn about the true source of their [...]
Original broadcast date: March 1, 2009 How do older drivers know when to turn in their keys? What are some of the physical factors that contribute to this decision? This life-changing decision is a flashpoint for debate about the impact of health upon the 30 million elderly drivers in the US and three million in [...]
Original broadcast date: January 6, 2008 When we last spoke to Dr. Ulli Krull, he talked about the development of a device that could be used to detect chemical substances in a given environment. For lack of a better analogy, it was like a Star Trek Tricorder. His present projects include developing biosensors that are [...]
Despite exposure to many cancer-causing agents or carcinogens in our environment, the human body has a way to repair damaged DNA that can prevent the development of tumours. A new study published November 11, 2008 in the online edition of Proceedings of the National Academy of Sciences of the USA (PNAS), scientists have identified a [...]
Researchers from University College London have gained a new understanding of how changes in the immune system can foreshadow the expression of Huntington’s disease by 16 years. The research on this fatal neurodegenerative disease was published online in the Journal of Experimental Medicine and shed some light on possible therapies that would target the immune [...]
We had read and heard of how through epidemiological studies how food can either promote or prevent the risk of developing the onset of certain cancers. A study published in a recent issue of the British Journal of Cancer looked at a mechanism that could explain this phenomenon that involves a person’s epigenetic code as [...]
Original broadcast date: March 9, 2008 With a greater understanding behind the mechanism or pathophysiology of disease, the ability to provide effective treatments can follow. An international consortium of scientists led by Oklahoma Medical Research Foundation investigator John B. Harley, M.D., Ph.D., has identified multiple genes linked to lupus, a devastating autoimmune disease that affects [...]
Multiple Sclerosis (MS) was first identified and described by a French neurologist, Dr. Jean-Martin Charcot, in 1868. It is the most common neurological disease affecting young adults in Canada. Women are twice as likely to develop MS as men. Every day, three more people in Canada are diagnosed with it. It can cause loss of [...]
Should pregnant women over the age of 35 have amniocentesis to check for birth defects and chromosomal abnormalities such as Down’s syndrome? In an opinion paper published in the Journal of Obstetrics and Gynaecology of Canada, the Society of Obstetricians and Gynaecologists of Canada recommends that maternal age should only factor into a decision about [...]
We have seen numerous studies in basic science research produce results that surprise the investigator and open up new insights into the pathophysiology or mechanism of disease. A study published in the July 13, 2006 online issue of the Journal of Clinical Investigation found that a protein previously linked to the development of type 2 [...]
Chronic stress seems to trigger the premature aging of immune system cells, a new study suggests. Although people who are under stress for long periods often look haggard, scientists don’t understand how chronic stress causes damage at the cellular level. The new research focused on one sign of biological aging – caps of DNA and [...]
Genetic research continues to broaden our understanding of the mechanism or pathophysiology of diseases. Reports seem to present themselves daily about new avenues for treatments of once incurable or uncontrollable illnesses. A team from the Scripps Research Institute and the University of California School of Medicine has developed compounds that reactivate the gene responsible for [...]
